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During active disease, some of these cavities are joined to the air passages bronchi and this material can be coughed up.It contains living bacteria, so can spread the infection.A person with fully susceptible MTB may develop secondary (acquired) resistance during therapy because of inadequate treatment, not taking the prescribed regimen appropriately (lack of compliance), or using low-quality medication.

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tuberculosis strain, the level of immunity in the uninfected person, and others.The cascade of person-to-person spread can be circumvented by segregating those with active ("overt") TB and putting them on anti-TB drug regimens.After about two weeks of effective treatment, subjects with nonresistant active infections generally do not remain contagious to others.However, the difficult culture process for this slow-growing organism can take two to six weeks for blood or sputum culture.Treatment of TB uses antibiotics to kill the bacteria.The recommended treatment of new-onset pulmonary tuberculosis, as of 2010, is six months of a combination of antibiotics containing rifampicin, isoniazid, pyrazinamide, and ethambutol for the first two months, and only rifampicin and isoniazid for the last four months.